| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
|---|
| Ligand | BDBM21279 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_466879 (CHEMBL930476) |
|---|
| IC50 | 3.5±n/a nM |
|---|
| Citation |  Lin, LS; Ha, S; Ball, RG; Tsou, NN; Castonguay, LA; Doss, GA; Fong, TM; Shen, CP; Xiao, JC; Goulet, MT; Hagmann, WK Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist. J Med Chem51:2108-14 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cannabinoid receptor 1 |
|---|
| Name: | Cannabinoid receptor 1 |
|---|
| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 52868.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21554 |
|---|
| Residue: | 472 |
|---|
| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
|
|
|
|---|
| BDBM21279 |
|---|
| n/a |
|---|
| Name | BDBM21279 |
|---|
| Synonyms: | 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | AM 251 | AM-251 | AM251 | CHEMBL285932 | N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21Cl2IN4O |
|---|
| Mol. Mass. | 555.239 |
|---|
| SMILES | Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
