| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM14756 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_466942 (CHEMBL933707) |
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| Ki | 44±n/a nM |
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| Citation |  Kulkarni, SS; Patel, MR; Talele, TT CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors. Bioorg Med Chem16:3675-86 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A |
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| Type: | Protein |
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| Mol. Mass.: | 88412.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233 |
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| Residue: | 779 |
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| Sequence: | MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP
KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC
NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE
SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC
RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR
IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF
VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD
LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM
TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY
NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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| BDBM14756 |
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| n/a |
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| Name | BDBM14756 |
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| Synonyms: | (R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline | 4-[(3R)-3-[(5-chloropyrimidin-2-yl)oxy]pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | 6,7-Dimethoxy-4-pyrrolidylquinazoline 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClN5O3 |
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| Mol. Mass. | 387.82 |
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| SMILES | COc1cc2ncnc(N3CC[C@H](C3)Oc3ncc(Cl)cn3)c2cc1OC |r| |
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| Structure | 
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