| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM50373195 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_467337 (CHEMBL939932) |
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| IC50 | 28±n/a nM |
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| Citation |  Asano, Y; Kitamura, S; Ohra, T; Aso, K; Igata, H; Tamura, T; Kawamoto, T; Tanaka, T; Sogabe, S; Matsumoto, S; Yamaguchi, M; Kimura, H; Itoh, F Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). Bioorg Med Chem16:4715-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM50373195 |
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| n/a |
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| Name | BDBM50373195 |
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| Synonyms: | CHEMBL259812 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20ClNO5S |
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| Mol. Mass. | 481.948 |
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| SMILES | COC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O |
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| Structure | 
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