Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGlucose-6-phosphate 1-dehydrogenase
LigandBDBM50070942
Substrate/Competitorn/a
Meas. Tech.ChEMBL_467395 (CHEMBL921928)
IC50 250±n/a nM
Citation Shin, ES; Park, J; Shin, JM; Cho, D; Cho, SY; Shin, DW; Ham, M; Kim, JB; Lee, TR Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorg Med Chem16:3580-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucose-6-phosphate 1-dehydrogenase
Name:Glucose-6-phosphate 1-dehydrogenase
Synonyms:G6PD | G6PD_YEAST | MET19 | ZWF1
Type:PROTEIN
Mol. Mass.:57518.83
Organism:Saccharomyces cerevisiae S288c
Description:ChEMBL_467395
Residue:505
Sequence:
MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEED
LKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVP
HRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEE
ELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIG
IIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDG
SKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVA
SGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYE
VLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQ
KHKYVMPEKHPYAWPVTKPEDTKDN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50070942
n/a
NameBDBM50070942
Synonyms:(-)-Epigallocatechin gallate | (-)-Epigallocatechin-3-o-gallate | (-)-epigallocatechin 3-gallate | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | CHEMBL297453 | EGCG | Epigallocatechin 3-gallate | Epigallocatechin monogallate, B | cid_65064
TypeSmall organic molecule
Emp. Form.C22H18O11
Mol. Mass.458.3717
SMILESOc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: