| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50373510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_467951 (CHEMBL947014) |
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| EC50 | 9.1±n/a nM |
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| Citation |  Chen, C; Jiang, W; Tran, JA; Tucci, FC; Fleck, BA; Markison, S; Wen, J; Madan, A; Hoare, SR; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Saunders, J Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett18:129-36 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50373510 |
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| n/a |
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| Name | BDBM50373510 |
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| Synonyms: | CHEMBL404069 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H46ClN5O3 |
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| Mol. Mass. | 596.203 |
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| SMILES | CC(C)[C@H](NC(=O)CN)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1)C1CCOCC1 |
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| Structure | 
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