Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50373688 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_468074 (CHEMBL931658) |
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IC50 | 200±n/a nM |
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Citation | Paquin, I; Raeppel, S; Leit, S; Gaudette, F; Zhou, N; Moradei, O; Saavedra, O; Bernstein, N; Raeppel, F; Bouchain, G; Fréchette, S; Woo, SH; Vaisburg, A; Fournel, M; Kalita, A; Robert, MF; Lu, A; Trachy-Bourget, MC; Yan, PT; Liu, J; Rahil, J; MacLeod, AR; Besterman, JM; Li, Z; Delorme, D Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett18:1067-71 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50373688 |
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n/a |
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Name | BDBM50373688 |
Synonyms: | CHEMBL404518 |
Type | Small organic molecule |
Emp. Form. | C19H18N8O |
Mol. Mass. | 374.3992 |
SMILES | Nc1nc(NCc2ccc(cc2)C(=O)Nc2ccccc2N)c2[nH]cnc2n1 |
Structure |
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