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TargetLysophosphatidic acid receptor Edg-4
LigandBDBM50373814
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468543
IC50 1300±n/a nM
Citation Beck HPKohn TRubenstein SHedberg CSchwandner RHasslinger KDai KLi CLiang LWesche HFrank BAn SWickramasinghe DJaen JMedina JHungate RShen W Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett 18:1037-41 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysophosphatidic acid receptor Edg-4
Name:Lysophosphatidic acid receptor Edg-4
Synonyms:LPA receptor 2 | LPA-2 | Lysophosphatidic acid receptor 2
Type:PROTEIN
Mol. Mass.:39103.44
Organism:Homo sapiens (Human)
Description:ChEMBL_1451385
Residue:351
Sequence:
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASN
RRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVA
TLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSR
MAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLV
KTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDA
EMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
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  Blast E-value cutoff:
BDBM50373814
n/a
NameBDBM50373814
Synonyms:CHEMBL270877
TypeSmall organic molecule
Emp. Form.C23H26F3N5O
Mol. Mass.445.4806
SMILESCOc1ccccc1N1CCN(C[C@H](C)Nc2nc(nc3ccccc23)C(F)(F)F)CC1
Structure
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