| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
|---|
| Ligand | BDBM50164236 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_468802 (CHEMBL932042) |
|---|
| IC50 | 4.4±n/a nM |
|---|
| Citation |  Mader, M; de Dios, A; Shih, C; Bonjouklian, R; Li, T; White, W; López de Uralde, B; Sánchez-Martinez, C; del Prado, M; Jaramillo, C; de Diego, E; Martín Cabrejas, LM; Dominguez, C; Montero, C; Shepherd, T; Dally, R; Toth, JE; Chatterjee, A; Pleite, S; Blanco-Urgoiti, J; Perez, L; Barberis, M; Lorite, MJ; Jambrina, E; Nevill, CR; Lee, PA; Schultz, RC; Wolos, JA; Li, LC; Campbell, RM; Anderson, BD Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett18:179-83 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 14 |
|---|
| Name: | Mitogen-activated protein kinase 14 |
|---|
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 41286.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16539 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
|
|
|
|---|
| BDBM50164236 |
|---|
| n/a |
|---|
| Name | BDBM50164236 |
|---|
| Synonyms: | 6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine; compound with methanesulfonic acid | CHEMBL363831 | CHEMBL404377 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25F2N5O2S |
|---|
| Mol. Mass. | 473.539 |
|---|
| SMILES | CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]c(nc1-c1ccc(F)cc1F)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
