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TargetHistone deacetylase 1
LigandBDBM50374013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468834 (CHEMBL947921)
IC50 1200±n/a nM
Citation Methot, JLChakravarty, PKChenard, MClose, JCruz, JCDahlberg, WKFleming, JHamblett, CLHamill, JEHarrington, PHarsch, AHeidebrecht, RHughes, BJung, JKenific, CMKral, AMMeinke, PTMiddleton, REOzerova, NSloman, DLStanton, MGSzewczak, AATyagarajan, SWitter, DJSecrist, JPMiller, TA Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett18:973-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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  Blast E-value cutoff:
BDBM50374013
n/a
NameBDBM50374013
Synonyms:CHEMBL438736
TypeSmall organic molecule
Emp. Form.C22H19NO2
Mol. Mass.329.3918
SMILESOc1ccc(cc1NC(=O)C\C=C\c1ccccc1)-c1ccccc1
Structure
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