| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50374045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468834 (CHEMBL947921) |
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| IC50 | >50000±n/a nM |
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| Citation |  Methot, JL; Chakravarty, PK; Chenard, M; Close, J; Cruz, JC; Dahlberg, WK; Fleming, J; Hamblett, CL; Hamill, JE; Harrington, P; Harsch, A; Heidebrecht, R; Hughes, B; Jung, J; Kenific, CM; Kral, AM; Meinke, PT; Middleton, RE; Ozerova, N; Sloman, DL; Stanton, MG; Szewczak, AA; Tyagarajan, S; Witter, DJ; Secrist, JP; Miller, TA Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett18:973-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50374045 |
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| n/a |
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| Name | BDBM50374045 |
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| Synonyms: | CHEMBL269947 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N3O3 |
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| Mol. Mass. | 333.3407 |
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| SMILES | Nc1ccc(cc1NC(=O)c1cccnc1)-c1ccc(cc1)C(O)=O |
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| Structure | 
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