| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 5 |
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| Ligand | BDBM50374011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468838 (CHEMBL947925) |
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| IC50 | >50000±n/a nM |
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| Citation |  Methot, JL; Chakravarty, PK; Chenard, M; Close, J; Cruz, JC; Dahlberg, WK; Fleming, J; Hamblett, CL; Hamill, JE; Harrington, P; Harsch, A; Heidebrecht, R; Hughes, B; Jung, J; Kenific, CM; Kral, AM; Meinke, PT; Middleton, RE; Ozerova, N; Sloman, DL; Stanton, MG; Szewczak, AA; Tyagarajan, S; Witter, DJ; Secrist, JP; Miller, TA Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett18:973-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 5 |
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| Name: | Histone deacetylase 5 |
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| Synonyms: | Antigen NY-CO-9 | HD5 | HDAC5 | HDAC5_HUMAN | Histone acetylase 5 (HDAC5) | Histone deacetylase 5 (HDAC5) | Human HDAC5 | KIAA0600 |
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| Type: | Enzyme |
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| Mol. Mass.: | 121968.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UQL6 |
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| Residue: | 1122 |
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| Sequence: | MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR
GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL
PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI
TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST
SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS
MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEED
CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ
SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP
CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM
GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS
AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS
ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET
EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
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| BDBM50374011 |
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| n/a |
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| Name | BDBM50374011 |
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| Synonyms: | CHEMBL437029 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31N5O3 |
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| Mol. Mass. | 521.6095 |
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| SMILES | C[C@H]1CN(CCN1C(=O)OCc1ccccc1)c1ccc(cn1)C(=O)Nc1cc(ccc1N)-c1ccccc1 |
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| Structure | 
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