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TargetWee1-like protein kinase
LigandBDBM50374065
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468879 (CHEMBL949042)
IC50 24±n/a nM
Citation Smaill, JBLee, HHPalmer, BDThompson, AMSquire, CJBaker, ENBooth, RJKraker, AHook, KDenny, WA Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg Med Chem Lett18:929-33 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50374065
n/a
NameBDBM50374065
Synonyms:CHEMBL270021
TypeSmall organic molecule
Emp. Form.C29H28ClN3O5
Mol. Mass.534.003
SMILESOCCn1c2cc(OCCCN3CCCC3)c(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Structure
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