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TargetMitogen-activated protein kinase 14
LigandBDBM50122385
Substrate/Competitorn/a
Meas. Tech.ChEMBL_468977 (CHEMBL952122)
IC50 0.100000±n/a nM
Citation Kolb, PHuang, DDey, FCaflisch, A Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model. J Med Chem51:1179-88 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50122385
n/a
NameBDBM50122385
Synonyms:5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-piperazin-1-ylmethyl-3,4-dihydro-1H-quinazolin-2-one | 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperazin-1-ylmethyl)-3,4-dihydroquinazolin-2(1H)-one | CHEMBL97227
TypeSmall organic molecule
Emp. Form.C25H23Cl3N4O
Mol. Mass.501.835
SMILESClc1ccccc1-c1cc(CN2CCNCC2)cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl
Structure
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