| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50122387 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468977 (CHEMBL952122) |
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| IC50 | 0.100000±n/a nM |
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| Citation |  Kolb, P; Huang, D; Dey, F; Caflisch, A Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model. J Med Chem51:1179-88 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50122387 |
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| n/a |
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| Name | BDBM50122387 |
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| Synonyms: | 5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-(piperidin-4-yloxy)-3,4-dihydro-1H-quinazolin-2-one | 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-yloxy)-3,4-dihydroquinazolin-2(1H)-one | CHEMBL327959 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21Cl3FN3O2 |
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| Mol. Mass. | 520.811 |
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| SMILES | Fc1ccc(c(Cl)c1)-c1cc(OC2CCNCC2)cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl |
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| Structure | 
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