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TargetCoagulation factor X
LigandBDBM50374274
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469192 (CHEMBL932218)
Ki 0.8±n/a nM
Citation Young, RJBorthwick, ADBrown, DBurns-Kurtis, CLCampbell, MChan, CCharbaut, MConvery, MADiallo, HHortense, EIrving, WRKelly, HAKing, NPKleanthous, SMason, AMPateman, AJPatikis, ANPinto, ILPollard, DRSenger, SShah, GPToomey, JRWatson, NSWeston, HEZhou, P Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg Med Chem Lett18:28-33 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50374274
n/a
NameBDBM50374274
Synonyms:CHEMBL403111
TypeSmall organic molecule
Emp. Form.C24H23ClFN5O3S2
Mol. Mass.548.053
SMILESCN(C)Cc1nccn1-c1ccc(N2CCC(NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 |w:16.17|
Structure
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