Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50328712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_469192 (CHEMBL932218) |
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Ki | 0.6±n/a nM |
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Citation | Young, RJ; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Charbaut, M; Convery, MA; Diallo, H; Hortense, E; Irving, WR; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Pateman, AJ; Patikis, AN; Pinto, IL; Pollard, DR; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Zhou, P Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg Med Chem Lett18:28-33 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50328712 |
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n/a |
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Name | BDBM50328712 |
Synonyms: | (S)-6-chloro-N-(1-(4-(2-((dimethylamino)methyl)-1H-imidazol-1-yl)-2-fluorophenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL1271369 |
Type | Small organic molecule |
Emp. Form. | C26H25ClFN5O3S |
Mol. Mass. | 542.025 |
SMILES | CN(C)Cc1nccn1-c1ccc(N2CC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)c(F)c1 |r| |
Structure |
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