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TargetOrexin/Hypocretin receptor type 1
LigandBDBM50374442
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469339 (CHEMBL932893)
Ki 2±n/a nM
Citation Bergman, JMRoecker, AJMercer, SPBednar, RAReiss, DRRansom, RWMeacham Harrell, CPettibone, DJLemaire, WMurphy, KLLi, CPrueksaritanont, TWinrow, CJRenger, JJKoblan, KSHartman, GDColeman, PJ Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett18:1425-30 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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  Blast E-value cutoff:
BDBM50374442
n/a
NameBDBM50374442
Synonyms:CHEMBL255763
TypeSmall organic molecule
Emp. Form.C26H27N5O2S
Mol. Mass.473.59
SMILESCc1ccc2nc(SCC(=O)N3CCC[C@H]3C(=O)Nc3ccccc3-n3cccc3)n(C)c2c1
Structure
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