| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-gamma serine/threonine-protein kinase |
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| Ligand | BDBM15169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_469475 (CHEMBL948034) |
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| IC50 | 2200±n/a nM |
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| Citation |  Zhao, Z; Robinson, RG; Barnett, SF; Defeo-Jones, D; Jones, RE; Hartman, GD; Huber, HE; Duggan, ME; Lindsley, CW Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett18:49-53 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-gamma serine/threonine-protein kinase |
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| Name: | RAC-gamma serine/threonine-protein kinase |
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| Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55769.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 479 |
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| Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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| BDBM15169 |
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| n/a |
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| Name | BDBM15169 |
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| Synonyms: | 1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one | 3-[1-[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)benzyl]-4-piperidyl]-1H-benzimidazol-2-one | imidazoquinoxaline | imidazoquinoxaline 16h |
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| Type | Small organic molecule |
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| Emp. Form. | C34H29N7O |
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| Mol. Mass. | 551.6404 |
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| SMILES | O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 |
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| Structure | 
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