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TargetTyrosine-protein kinase Lck
LigandBDBM50374625
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469608 (CHEMBL934187)
IC50 5±n/a nM
Citation Martin, MWNewcomb, JNunes, JJBoucher, CChai, LEpstein, LFFaust, TFlores, SGallant, PGore, AGu, YHsieh, FHuang, XKim, JLMiddleton, SMorgenstern, KOliveira-dos-Santos, APatel, VFPowers, DRose, PTudor, YTurci, SMWelcher, AAZack, DZhao, HZhu, LZhu, XGhiron, CErmann, MJohnston, DSaluste, CG Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem51:1637-48 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Lck
Name:Tyrosine-protein kinase Lck
Synonyms:2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:n/a
Mol. Mass.:57987.83
Organism:Homo sapiens (Human)
Description:P06239
Residue:509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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  Blast E-value cutoff:
BDBM50374625
n/a
NameBDBM50374625
Synonyms:CHEMBL403522
TypeSmall organic molecule
Emp. Form.C32H32N8O2
Mol. Mass.560.6489
SMILESCOc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1N1CCN(C)CC1 |(-2.95,-19.43,;-4.29,-20.2,;-4.29,-21.74,;-2.96,-22.51,;-2.97,-24.05,;-1.64,-24.82,;-.3,-24.05,;-.3,-22.51,;1.02,-21.74,;2.36,-22.5,;2.36,-24.05,;1.03,-24.83,;3.7,-24.82,;4.02,-26.32,;3.11,-27.55,;3.73,-28.96,;5.26,-29.13,;6.16,-27.89,;5.55,-26.49,;6.18,-25.09,;5.04,-24.05,;5.04,-22.5,;6.37,-21.74,;6.37,-20.2,;5.03,-19.44,;7.7,-19.43,;9.04,-20.2,;9.03,-21.75,;7.7,-22.51,;7.69,-24.05,;3.7,-21.73,;3.7,-20.19,;-4.29,-24.82,;-5.62,-24.05,;-5.63,-22.51,;-6.96,-21.74,;-6.95,-20.2,;-8.28,-19.43,;-9.62,-20.19,;-10.95,-19.42,;-9.62,-21.73,;-8.29,-22.51,)|
Structure
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