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TargetCasein Kinase II
LigandBDBM50374651
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469783
Ki 2.2±n/a nM
Citation Nie ZPerretta CErickson PMargosiak SLu JAverill AAlmassy RChu S Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities. Bioorg Med Chem Lett 18:619-23 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Casein Kinase II
Name:Casein Kinase II
Synonyms:CK II | CK2- alpha
Type:Enzyme
Mol. Mass.:39238.74
Organism:Zea mays (Maize)
Description:n/a
Residue:332
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKC
IIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLY
PTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPG
KEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKI
AKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLL
RYDHQERLTALEAMTHPYFQQVRAAENSRTRA
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BDBM50374651
n/a
NameBDBM50374651
Synonyms:CHEMBL257219
TypeSmall organic molecule
Emp. Form.C31H37N9O2
Mol. Mass.567.6846
SMILESCCN(CC)C1CCN(C1)C(=O)c1cccc(Nc2nc3Nc4cccc(NC(=O)CCCCc5cnn2c5n3)c4)c1 |w:5.4|
Structure
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