| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha |
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| Ligand | BDBM50374655 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_469783 (CHEMBL947049) |
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| Ki | 2.4±n/a nM |
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| Citation |  Nie, Z; Perretta, C; Erickson, P; Margosiak, S; Lu, J; Averill, A; Almassy, R; Chu, S Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities. Bioorg Med Chem Lett18:619-23 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha |
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| Name: | Casein kinase II subunit alpha |
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| Synonyms: | ACK2 | CK II | CK2- alpha | CSK2A_MAIZE | Casein Kinase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 39238.74 |
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| Organism: | Zea mays (Maize) |
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| Description: | n/a |
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| Residue: | 332 |
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| Sequence: | MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKC
IIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLY
PTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPG
KEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKI
AKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLL
RYDHQERLTALEAMTHPYFQQVRAAENSRTRA
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| BDBM50374655 |
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| n/a |
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| Name | BDBM50374655 |
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| Synonyms: | CHEMBL401945 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37N9O2 |
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| Mol. Mass. | 555.6739 |
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| SMILES | CCN(CC)CCN(C)C(=O)c1cccc(Nc2nc3Nc4cccc(NC(=O)CCCCc5cnn2c5n3)c4)c1 |
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| Structure | 
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