| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM50374686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_469831 (CHEMBL949020) |
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| IC50 | 9±n/a nM |
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| Citation |  Goldberg, DR; Choi, Y; Cogan, D; Corson, M; DeLeon, R; Gao, A; Gruenbaum, L; Hao, MH; Joseph, D; Kashem, MA; Miller, C; Moss, N; Netherton, MR; Pargellis, CP; Pelletier, J; Sellati, R; Skow, D; Torcellini, C; Tseng, YC; Wang, J; Wasti, R; Werneburg, B; Wu, JP; Xiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett18:938-41 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM50374686 |
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| n/a |
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| Name | BDBM50374686 |
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| Synonyms: | CHEMBL403286 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O3S |
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| Mol. Mass. | 542.652 |
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| SMILES | CC1CNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc(cs1)C(=O)NC1CCN(Cc2ccccc2)CC1 |w:1.0| |
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| Structure | 
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