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TargetMAP kinase-activated protein kinase 2
LigandBDBM50374689
Substrate/Competitorn/a
Meas. Tech.ChEMBL_469831 (CHEMBL949020)
IC50 7±n/a nM
Citation Goldberg, DRChoi, YCogan, DCorson, MDeLeon, RGao, AGruenbaum, LHao, MHJoseph, DKashem, MAMiller, CMoss, NNetherton, MRPargellis, CPPelletier, JSellati, RSkow, DTorcellini, CTseng, YCWang, JWasti, RWerneburg, BWu, JPXiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett18:938-41 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-activated protein kinase 2
Name:MAP kinase-activated protein kinase 2
Synonyms:MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:Serine/threonine-protein kinase
Mol. Mass.:45579.87
Organism:Homo sapiens (Human)
Description:P49137
Residue:400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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  Blast E-value cutoff:
BDBM50374689
n/a
NameBDBM50374689
Synonyms:CHEMBL256196
TypeSmall organic molecule
Emp. Form.C24H28N6O3S
Mol. Mass.480.583
SMILESCCN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC(C)n4c3c2)n1 |w:28.29|
Structure
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