| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 14 |
|---|
| Ligand | BDBM50374681 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_469844 (CHEMBL949032) |
|---|
| IC50 | 480±n/a nM |
|---|
| Citation |  Goldberg, DR; Choi, Y; Cogan, D; Corson, M; DeLeon, R; Gao, A; Gruenbaum, L; Hao, MH; Joseph, D; Kashem, MA; Miller, C; Moss, N; Netherton, MR; Pargellis, CP; Pelletier, J; Sellati, R; Skow, D; Torcellini, C; Tseng, YC; Wang, J; Wasti, R; Werneburg, B; Wu, JP; Xiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett18:938-41 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 14 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 14 |
|---|
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 104059.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99558 |
|---|
| Residue: | 947 |
|---|
| Sequence: | MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
|
|
|
|---|
| BDBM50374681 |
|---|
| n/a |
|---|
| Name | BDBM50374681 |
|---|
| Synonyms: | CHEMBL257834 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36N6O3S |
|---|
| Mol. Mass. | 548.7 |
|---|
| SMILES | CC(C)(C)CN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC5(CCC5)n4c3c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
