| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Ligand | BDBM2691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_470248 (CHEMBL950203) |
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| IC50 | 380±n/a nM |
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| Citation |  Levy, DE; Wang, DX; Lu, Q; Chen, Z; Perumattam, J; Xu, YJ; Higaki, J; Dong, H; Liclican, A; Laney, M; Mavunkel, B; Dugar, S Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether. Bioorg Med Chem Lett18:2395-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Name: | Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Synonyms: | CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56419.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13557 |
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| Residue: | 499 |
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| Sequence: | MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
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| BDBM2691 |
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| n/a |
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| Name | BDBM2691 |
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| Synonyms: | 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | BIM-3 | Bisindolyl deriv. 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20N4O2 |
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| Mol. Mass. | 384.4305 |
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| SMILES | NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 |t:7| |
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| Structure | 
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