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TargetLanosterol 14-alpha demethylase
LigandBDBM50375213
Substrate/Competitorn/a
Meas. Tech.ChEMBL_470401 (CHEMBL939288)
Kd 400±n/a nM
Citation Korosec, TAcimovic, JSeliskar, MKocjan, DTacer, KFRozman, DUrleb, U Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). Bioorg Med Chem16:209-21 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lanosterol 14-alpha demethylase
Name:Lanosterol 14-alpha demethylase
Synonyms:CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase
Type:Protein
Mol. Mass.:56817.21
Organism:Homo sapiens (Human)
Description:Q16850
Residue:503
Sequence:
MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKS
PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK
EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE
VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL
NLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP
TVNYTTMIHTPENPVIRYKRRSK
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BDBM50375213
n/a
NameBDBM50375213
Synonyms:CHEMBL537002
TypeSmall organic molecule
Emp. Form.C18H22Cl2N2O
Mol. Mass.353.286
SMILESCCCN(CCc1ccc(Cl)c(Cl)c1)CC(O)c1cccnc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: