| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
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| Ligand | BDBM50375309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_470779 (CHEMBL934981) |
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| IC50 | >200000±n/a nM |
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| Citation |  Ekins, S; Mankowski, DC; Hoover, DJ; Lawton, MP; Treadway, JL; Harwood, HJ Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos35:493-500 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14-alpha demethylase |
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| Name: | Lanosterol 14-alpha demethylase |
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| Synonyms: | CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase |
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| Type: | Protein |
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| Mol. Mass.: | 56817.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16850 |
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| Residue: | 509 |
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| Sequence: | MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIRYKRRSK
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| BDBM50375309 |
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| n/a |
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| Name | BDBM50375309 |
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| Synonyms: | BAY-5360 | Flagyl | Flagyl 375 | Flagyl ER | Flagyl i.v. rtu in plastic container | METRONIDAZOLE | Metric 21 | Metro IV | Metro i.v. | MetroGel | Metrocream | Metrogel-vaginal | Metrolotion | Metrolyl | Metromidol |
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| Type | Small organic molecule |
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| Emp. Form. | C6H9N3O3 |
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| Mol. Mass. | 171.154 |
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| SMILES | Cc1ncc(n1CCO)[N+]([O-])=O |
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| Structure | 
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