Ki Summary

Reaction Details

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Target

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Ligand

BDBM50226168

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_470908 (CHEMBL937006)

IC50

41800±n/a nM

Citation

Pak, VV; Koo, M; Kim, MJ; Yun, L; Kwon, DY Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem16:1309-18 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Synonyms:

HMDH_MESAU | HMG-CoA reductase | HMGCR

Type:

PROTEIN

Mol. Mass.:

96954.46

Organism:

Mesocricetus auratus

Description:

ChEMBL_470908

Residue:

887

Sequence:

MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTTEHSKVSLGLDEDVSKR
IEPSVSLWQFYLSKMISMDIEQVVTLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVAT
PKKAPDNCCRREPVLSRRNEKLSSVEEEPGVNQDRKVEVIKPLVAETESTSRATFVLGAS
GGCSPVALGTQEPEIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSTKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACD
SAEVKAWLETPEGFAVIKDAFDSTSRFARLQKLHVTMAGRNLYIRFQSKTGDAMGMNMIS
KGTEKALVKLQEFFPEMQILAVSGNYCTDKKPAAVNWIEGRGKTVVCEAVIPARVVREVL
KTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA

BDBM50226168

n/a

Name

BDBM50226168

Synonyms:

CHEMBL411443 | YVAE

Type

Small organic molecule

Emp. Form.

C22H32N4O8

Mol. Mass.

480.5115

SMILES

CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Structure