Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Yes |
---|
Ligand | BDBM50221566 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_473236 (CHEMBL932927) |
---|
IC50 | 0.3±n/a nM |
---|
Citation | Palanki, MS; Akiyama, H; Campochiaro, P; Cao, J; Chow, CP; Dellamary, L; Doukas, J; Fine, R; Gritzen, C; Hood, JD; Hu, S; Kachi, S; Kang, X; Klebansky, B; Kousba, A; Lohse, D; Mak, CC; Martin, M; McPherson, A; Pathak, VP; Renick, J; Soll, R; Umeda, N; Yee, S; Yokoi, K; Zeng, B; Zhu, H; Noronha, G Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. J Med Chem51:1546-59 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Yes |
---|
Name: | Tyrosine-protein kinase Yes |
Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
Type: | Protein |
Mol. Mass.: | 60801.54 |
Organism: | Homo sapiens (Human) |
Description: | P07947 |
Residue: | 543 |
Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
BDBM50221566 |
---|
n/a |
---|
Name | BDBM50221566 |
Synonyms: | 4-chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol | 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenol | CHEMBL400402 | US8481536, 449 | US8481536, 597 |
Type | Small organic molecule |
Emp. Form. | C26H26ClN5O2 |
Mol. Mass. | 475.97 |
SMILES | Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1cc(O)ccc1Cl |
Structure |
|