Ki Summary

Reaction Details

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Target

Calcium/calmodulin-dependent protein kinase kinase 2

Ligand

BDBM15211

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_473615 (CHEMBL940168)

29700±n/a nM

Citation

Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A104:20523-8 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcium/calmodulin-dependent protein kinase kinase 2

Name:

Calcium/calmodulin-dependent protein kinase kinase 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64746.61

Organism:

Homo sapiens (Human)

Description:

gi_27437015

Residue:

588

Sequence:

MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE

BDBM15211

n/a

Name

BDBM15211

Synonyms:

CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide | N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide

Type

Small organic molecule

Emp. Form.

C20H20BrN3O2S

Mol. Mass.

446.361

SMILES

Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1

Structure