| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic elongation factor 2 kinase |
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| Ligand | BDBM50375667 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_473812 (CHEMBL937076) |
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| IC50 | 440±n/a nM |
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| Citation |  Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A104:20523-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic elongation factor 2 kinase |
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| Name: | Eukaryotic elongation factor 2 kinase |
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| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K |
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| Type: | Protein |
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| Mol. Mass.: | 82116.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 725 |
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| Sequence: | MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
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| BDBM50375667 |
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| n/a |
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| Name | BDBM50375667 |
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| Synonyms: | CHEMBL437612 | TX-1918 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12O3 |
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| Mol. Mass. | 228.2433 |
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| SMILES | [#6]-c1cc(\[#6]=[#6]-2\[#6](=O)-[#6]=[#6]-[#6]-2=O)cc(-[#6])c1-[#8] |c:8| |
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| Structure | 
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