Reaction Details |
| Report a problem with these data |
Target | Geranylgeranyl pyrophosphate synthase BTS1 |
---|
Ligand | BDBM25284 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_474166 (CHEMBL938424) |
---|
Ki | 80±n/a nM |
---|
Citation | Guo, RT; Cao, R; Liang, PH; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A104:10022-7 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Geranylgeranyl pyrophosphate synthase BTS1 |
---|
Name: | Geranylgeranyl pyrophosphate synthase BTS1 |
Synonyms: | BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase (GGPPS) | Geranylgeranyl pyrophosphate synthase |
Type: | Protein |
Mol. Mass.: | 38647.44 |
Organism: | Saccharomyces cerevisiae (Yeast) |
Description: | n/a |
Residue: | 335 |
Sequence: | MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIV
SQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTK
EPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRL
MEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVH
ALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
NDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
|
|
|
BDBM25284 |
---|
n/a |
---|
Name | BDBM25284 |
Synonyms: | (1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phenyl]phenyl}-1-phosphonoethyl)phosphonic acid | BPH-675 | bisphosphonate, 6 |
Type | Small organic molecule |
Emp. Form. | C24H23NO9P2S |
Mol. Mass. | 563.453 |
SMILES | OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O |
Structure |
|