Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM25289 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_474168 (CHEMBL938426) |
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Ki | 110±n/a nM |
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Citation | Guo, RT; Cao, R; Liang, PH; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A104:10022-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM25289 |
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n/a |
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Name | BDBM25289 |
Synonyms: | bisphosphonate, 38 | {1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phosphonoethyl}phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C20H20O8P2 |
Mol. Mass. | 450.3155 |
SMILES | OC(COc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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