Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase BTS1 |
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Ligand | BDBM12578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_474166 (CHEMBL938424) |
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Ki | 260±n/a nM |
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Citation | Guo, RT; Cao, R; Liang, PH; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A104:10022-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase BTS1 |
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Name: | Geranylgeranyl pyrophosphate synthase BTS1 |
Synonyms: | BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase (GGPPS) | Geranylgeranyl pyrophosphate synthase |
Type: | Protein |
Mol. Mass.: | 38647.44 |
Organism: | Saccharomyces cerevisiae (Yeast) |
Description: | n/a |
Residue: | 335 |
Sequence: | MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIV
SQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTK
EPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRL
MEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVH
ALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
NDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
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BDBM12578 |
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n/a |
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Name | BDBM12578 |
Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O7P2 |
Mol. Mass. | 272.0896 |
SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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