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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50375792 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_474267 (CHEMBL935072) | ||
| IC50 | 0.7±n/a nM | ||
| Citation |  Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett18:2222-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50375792 | |||
| n/a | |||
| Name | BDBM50375792 | ||
| Synonyms: | CHEMBL257236 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H12Cl3NO2 | ||
| Mol. Mass. | 416.684 | ||
| SMILES | Oc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(-.42,-39.44,;-1.76,-40.22,;-1.75,-41.76,;-3.08,-42.53,;-3.08,-44.07,;-4.42,-44.84,;-4.42,-46.38,;-3.09,-47.15,;-1.75,-46.37,;-1.75,-44.83,;-.42,-44.06,;-4.41,-41.76,;-5.74,-42.53,;-7.07,-41.76,;-7.07,-40.22,;-8.41,-39.45,;-5.74,-39.44,;-5.74,-37.9,;-7.06,-37.13,;-8.4,-37.9,;-7.07,-35.59,;-5.73,-34.82,;-4.39,-35.59,;-4.39,-37.13,;-3.06,-37.9,;-4.41,-40.22,;-3.09,-39.45,)| | ||
| Structure | 
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