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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50375795 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_474267 (CHEMBL935072) | ||
| IC50 | 0.57±n/a nM | ||
| Citation |  Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett18:2222-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50375795 | |||
| n/a | |||
| Name | BDBM50375795 | ||
| Synonyms: | CHEMBL403389 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H22Cl3N3O3 | ||
| Mol. Mass. | 530.83 | ||
| SMILES | NCCC(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(28.21,-17.45,;26.85,-16.74,;26.79,-15.19,;25.5,-14.3,;24.25,-15.23,;25.47,-12.76,;24.12,-12.02,;22.8,-12.81,;21.45,-12.07,;20.13,-12.86,;20.15,-14.4,;18.83,-15.19,;18.85,-16.73,;17.52,-17.51,;17.54,-19.05,;18.89,-19.81,;20.22,-19.01,;20.19,-17.48,;21.51,-16.68,;17.49,-14.44,;16.18,-15.22,;14.83,-14.48,;14.81,-12.94,;13.47,-12.19,;16.13,-12.14,;16.11,-10.6,;14.78,-9.85,;13.46,-10.64,;14.75,-8.31,;16.08,-7.52,;17.43,-8.27,;17.45,-9.81,;18.79,-10.56,;17.47,-12.9,;18.79,-12.12,)| | ||
| Structure | 
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