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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50375805 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_474267 (CHEMBL935072) | ||
| IC50 | 1.5±n/a nM | ||
| Citation |  Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett18:2222-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50375805 | |||
| n/a | |||
| Name | BDBM50375805 | ||
| Synonyms: | CHEMBL403925 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H14Cl3NO2 | ||
| Mol. Mass. | 430.711 | ||
| SMILES | COc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(13.91,-23.23,;13.92,-24.77,;12.59,-25.55,;12.59,-27.09,;11.26,-27.86,;11.26,-29.4,;9.92,-30.17,;9.92,-31.71,;11.25,-32.48,;12.59,-31.7,;12.59,-30.16,;13.92,-29.39,;9.93,-27.09,;8.6,-27.86,;7.27,-27.09,;7.27,-25.55,;5.93,-24.78,;8.6,-24.77,;8.6,-23.23,;7.28,-22.46,;5.94,-23.24,;7.27,-20.93,;8.61,-20.15,;9.95,-20.92,;9.95,-22.46,;11.28,-23.23,;9.93,-25.55,;11.26,-24.78,)| | ||
| Structure | 
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