| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
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| Ligand | BDBM50236856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_474823 (CHEMBL950240) |
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| IC50 | 27±n/a nM |
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| Citation |  Weiss, MM; Harmange, JC; Polverino, AJ; Bauer, D; Berry, L; Berry, V; Borg, G; Bready, J; Chen, D; Choquette, D; Coxon, A; DeMelfi, T; Doerr, N; Estrada, J; Flynn, J; Graceffa, RF; Harriman, SP; Kaufman, S; La, DS; Long, A; Neervannan, S; Patel, VF; Potashman, M; Regal, K; Roveto, PM; Schrag, ML; Starnes, C; Tasker, A; Teffera, Y; Whittington, DA; Zanon, R Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors. J Med Chem51:1668-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lyn |
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| Name: | Tyrosine-protein kinase Lyn |
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| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
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| Type: | Protein |
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| Mol. Mass.: | 58575.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07948 |
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| Residue: | 512 |
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| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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| BDBM50236856 |
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| n/a |
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| Name | BDBM50236856 |
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| Synonyms: | CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O4 |
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| Mol. Mass. | 414.4532 |
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| SMILES | COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC |
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| Structure | 
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