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TargetTyrosine-protein kinase Lck
LigandBDBM50376007
Substrate/Competitorn/a
Meas. Tech.ChEMBL_474790 (CHEMBL951283)
IC50 4300±n/a nM
Citation Weiss, MMHarmange, JCPolverino, AJBauer, DBerry, LBerry, VBorg, GBready, JChen, DChoquette, DCoxon, ADeMelfi, TDoerr, NEstrada, JFlynn, JGraceffa, RFHarriman, SPKaufman, SLa, DSLong, ANeervannan, SPatel, VFPotashman, MRegal, KRoveto, PMSchrag, MLStarnes, CTasker, ATeffera, YWhittington, DAZanon, R Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors. J Med Chem51:1668-80 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Lck
Name:Tyrosine-protein kinase Lck
Synonyms:2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:n/a
Mol. Mass.:57987.83
Organism:Homo sapiens (Human)
Description:P06239
Residue:509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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  Blast E-value cutoff:
BDBM50376007
n/a
NameBDBM50376007
Synonyms:CHEMBL406914
TypeSmall organic molecule
Emp. Form.C26H26N2O4
Mol. Mass.430.4956
SMILESCOc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC(C)(C)C)c2cc1OC
Structure
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