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TargetCytochrome P450 2D6
LigandBDBM50376019
Substrate/Competitorn/a
Meas. Tech.ChEMBL_474878 (CHEMBL932841)
IC50>50000±n/a nM
Citation Harmange, JCWeiss, MMGermain, JPolverino, AJBorg, GBready, JChen, DChoquette, DCoxon, ADeMelfi, TDiPietro, LDoerr, NEstrada, JFlynn, JGraceffa, RFHarriman, SPKaufman, SLa, DSLong, AMartin, MWNeervannan, SPatel, VFPotashman, MRegal, KRoveto, PMSchrag, MLStarnes, CTasker, ATeffera, YWang, LWhite, RDWhittington, DAZanon, R Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation. J Med Chem51:1649-67 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50376019
n/a
NameBDBM50376019
Synonyms:CHEMBL429585
TypeSmall organic molecule
Emp. Form.C28H20ClFN2O4
Mol. Mass.502.921
SMILESCOc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Structure
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