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TargetMitogen-activated protein kinase 8
LigandBDBM50376125
Substrate/Competitorn/a
Meas. Tech.ChEMBL_475208 (CHEMBL921936)
IC50 480±n/a nM
Citation Asano, YKitamura, SOhra, TItoh, FKajino, MTamura, TKaneko, MIkeda, SIgata, HKawamoto, TSogabe, SMatsumoto, STanaka, TYamaguchi, MKimura, HFukumoto, S Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2). Bioorg Med Chem16:4699-714 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 8
Name:Mitogen-activated protein kinase 8
Synonyms:Jnk1 | MK08_RAT | Mapk8 | Prkm8
Type:PROTEIN
Mol. Mass.:46809.57
Organism:Rattus norvegicus
Description:ChEMBL_475208
Residue:411
Sequence:
MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
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  Blast E-value cutoff:
BDBM50376125
n/a
NameBDBM50376125
Synonyms:CHEMBL411083
TypeSmall organic molecule
Emp. Form.C25H22ClF2N3O4S
Mol. Mass.533.975
SMILESCCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(n(CC(F)F)n1)S(C)(=O)=O
Structure
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