Reaction Details |
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Target | Mitogen-activated protein kinase 8 |
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Ligand | BDBM50376125 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_475208 (CHEMBL921936) |
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IC50 | 480±n/a nM |
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Citation | Asano, Y; Kitamura, S; Ohra, T; Itoh, F; Kajino, M; Tamura, T; Kaneko, M; Ikeda, S; Igata, H; Kawamoto, T; Sogabe, S; Matsumoto, S; Tanaka, T; Yamaguchi, M; Kimura, H; Fukumoto, S Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2). Bioorg Med Chem16:4699-714 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 8 |
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Name: | Mitogen-activated protein kinase 8 |
Synonyms: | Jnk1 | MK08_RAT | Mapk8 | Prkm8 |
Type: | PROTEIN |
Mol. Mass.: | 46809.57 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_475208 |
Residue: | 411 |
Sequence: | MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
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BDBM50376125 |
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n/a |
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Name | BDBM50376125 |
Synonyms: | CHEMBL411083 |
Type | Small organic molecule |
Emp. Form. | C25H22ClF2N3O4S |
Mol. Mass. | 533.975 |
SMILES | CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(n(CC(F)F)n1)S(C)(=O)=O |
Structure |
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