| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic Anhydrase III |
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| Ligand | BDBM10883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_475786 |
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| Ki | 630000±n/a nM |
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| Citation |  Di Fiore A; Pedone C; Antel J; Waldeck H; Witte A; Wurl M; Scozzafava A; Supuran CT; De Simone G Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors. Bioorg Med Chem Lett 18:2669-74 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic Anhydrase III |
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| Name: | Carbonic Anhydrase III |
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| Synonyms: | CA-III | Carbonate dehydratase III | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29562.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human cloned isozyme. |
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| Residue: | 260 |
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| Sequence: | MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
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| BDBM10883 |
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| n/a |
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| Name | BDBM10883 |
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| Synonyms: | 4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 | Dichlorophenamide | Dichlorophenamide (DCP) | Dichlorophenamide, DCP | Sulfonamide, 4 | US10172837, Dichlorphenamide | sulfonamide 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H6Cl2N2O4S2 |
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| Mol. Mass. | 305.159 |
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| SMILES | NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O |
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| Structure | 
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