| Reaction Details |
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 | Report a problem with these data |
| Target | CAAX prenyl protease 1 homolog |
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| Ligand | BDBM578 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_476919 (CHEMBL924570) |
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| IC50 | 18400±n/a nM |
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| Citation |  Coffinier, C; Hudon, SE; Farber, EA; Chang, SY; Hrycyna, CA; Young, SG; Fong, LG HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A104:13432-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| CAAX prenyl protease 1 homolog |
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| Name: | CAAX prenyl protease 1 homolog |
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| Synonyms: | FACE-1 | FACE1_MOUSE | Face1 | Farnesylated proteins-converting enzyme 1 | Prenyl protein-specific endoprotease 1 | Zinc metalloproteinase Ste24 homolog | Zmpste24 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54735.85 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_476919 |
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| Residue: | 475 |
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| Sequence: | MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMD
SDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEI
IQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLEFFMKDAIKKFIVTQCILLP
VSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEV
MAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGM
EARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCF
FLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADA
FAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
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| BDBM578 |
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| n/a |
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| Name | BDBM578 |
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| Synonyms: | (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide | ABT-378 | Aluviran | CHEMBL729 | LPV | Lopinavir |
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| Type | Small organic molecule |
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| Emp. Form. | C37H48N4O5 |
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| Mol. Mass. | 628.8008 |
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| SMILES | CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)Cc1ccccc1 |r| |
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| Structure | 
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