| Reaction Details |
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 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
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| Ligand | BDBM50376747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_477735 (CHEMBL926069) |
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| IC50 | 63±n/a nM |
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| Citation |  De Cian, A; Cristofari, G; Reichenbach, P; De Lemos, E; Monchaud, D; Teulade-Fichou, MP; Shin-Ya, K; Lacroix, L; Lingner, J; Mergny, JL Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A104:17347-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomerase reverse transcriptase |
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| Name: | Telomerase reverse transcriptase |
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| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127099.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1447029 |
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| Residue: | 1132 |
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| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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| BDBM50376747 |
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| n/a |
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| Name | BDBM50376747 |
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| Synonyms: | CHEMBL409247 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N5O2 |
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| Mol. Mass. | 449.5027 |
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| SMILES | C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 |
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| Structure | 
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