| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
|---|
| Ligand | BDBM50376901 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_478599 (CHEMBL922440) |
|---|
| Ki | 5.97±n/a nM |
|---|
| Citation |  Hu, SX; Soll, R; Yee, S; Lohse, DL; Kousba, A; Zeng, B; Yu, X; McPherson, A; Renick, J; Cao, J; Tabak, A; Hood, J; Doukas, J; Noronha, G; Martin, M Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrr Drug Metab Dispos35:929-36 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Yes |
|---|
| Name: | Tyrosine-protein kinase Yes |
|---|
| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60801.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07947 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
|---|
| BDBM50376901 |
|---|
| n/a |
|---|
| Name | BDBM50376901 |
|---|
| Synonyms: | CHEMBL256101 | TG-100855 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25Cl2N5O2 |
|---|
| Mol. Mass. | 510.415 |
|---|
| SMILES | Cc1cc(cc2nnc(Nc3ccc(OCC[N+]4([O-])CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
