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TargetBcl2-associated agonist of cell death
LigandBDBM50376902
Substrate/Competitorn/a
Meas. Tech.ChEMBL_478760 (CHEMBL936491)
Ki 1000±n/a nM
Citation Nguyen, MMarcellus, RCRoulston, AWatson, MSerfass, LMurthy Madiraju, SRGoulet, DViallet, JBélec, LBillot, XAcoca, SPurisima, EWiegmans, ACluse, LJohnstone, RWBeauparlant, PShore, GC Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A104:19512-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl2-associated agonist of cell death
Name:Bcl2-associated agonist of cell death
Synonyms:BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:PROTEIN
Mol. Mass.:18393.69
Organism:Homo sapiens (Human)
Description:ChEMBL_478760
Residue:168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
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  Blast E-value cutoff:
BDBM50376902
n/a
NameBDBM50376902
Synonyms:CHEMBL408194
TypeSmall organic molecule
Emp. Form.C20H19N3O
Mol. Mass.317.3844
SMILESCOC1=CC(=N\C1=C/c1[nH]c(C)cc1C)c1cc2ccccc2[nH]1 |c:4,t:2|
Structure
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