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TargetEquilibrative nucleoside transporter 1
LigandBDBM50376975
Substrate/Competitorn/a
Meas. Tech.ChEMBL_478939 (CHEMBL936365)
Ki 0.45±n/a nM
Citation Zhu, Z; Buolamwini, JK Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem16:3848-65 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Equilibrative nucleoside transporter 1
Name:Equilibrative nucleoside transporter 1
Synonyms:ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:Multi-pass membrane protein
Mol. Mass.:50225.92
Organism:Homo sapiens (Human)
Description:n/a
Residue:456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50376975
n/a
NameBDBM50376975
Synonyms:CHEMBL260570
TypeSmall organic molecule
Emp. Form.C19H20N6O6
Mol. Mass.428.3987
SMILESOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(ncnc12)N1CCc2ccc(cc2C1)[N+]([O-])=O
Structure
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