| Reaction Details |
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 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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| Ligand | BDBM50377140 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479334 (CHEMBL921617) |
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| IC50 | 731±n/a nM |
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| Citation |  Bingham, AH; Davenport, RJ; Fosbeary, R; Gowers, L; Knight, RL; Lowe, C; Owen, DA; Parry, DM; Pitt, WR Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors. Bioorg Med Chem Lett18:3622-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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| Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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| Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84642.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_327453 |
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| Residue: | 745 |
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| Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
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| BDBM50377140 |
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| n/a |
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| Name | BDBM50377140 |
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| Synonyms: | CHEMBL254793 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N6OS |
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| Mol. Mass. | 390.462 |
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| SMILES | NCCC(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc3ncsc3c2)n1 |
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| Structure | 
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