| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50377216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479361 (CHEMBL921644) |
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| Ki | 3±n/a nM |
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| Citation |  McAtee, JJ; Dodson, JW; Dowdell, SE; Girard, GR; Goodman, KB; Hilfiker, MA; Sehon, CA; Sha, D; Wang, GZ; Wang, N; Viet, AQ; Zhang, D; Aiyar, NV; Behm, DJ; Carballo, LH; Evans, CA; Fries, HE; Nagilla, R; Roethke, TJ; Xu, X; Yuan, CC; Douglas, SA; Neeb, MJ Development of potent and selective small-molecule human Urotensin-II antagonists. Bioorg Med Chem Lett18:3500-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42159.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Urotensin-II UTS2R HUMAN::Q9UKP6 |
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| Residue: | 389 |
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| Sequence: | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
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| BDBM50377216 |
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| n/a |
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| Name | BDBM50377216 |
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| Synonyms: | CHEMBL256988 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28Cl2N4O3 |
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| Mol. Mass. | 515.432 |
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| SMILES | Clc1cc2ncc(=O)n(CC(=O)N3CCCC(C3CN3CCOCC3)c3ccccc3)c2cc1Cl |w:17.18,16.26| |
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| Structure | 
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