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TargetCytochrome P450 2D6
LigandBDBM50377216
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479363 (CHEMBL921646)
IC50 21000±n/a nM
Citation McAtee, JJDodson, JWDowdell, SEGirard, GRGoodman, KBHilfiker, MASehon, CASha, DWang, GZWang, NViet, AQZhang, DAiyar, NVBehm, DJCarballo, LHEvans, CAFries, HENagilla, RRoethke, TJXu, XYuan, CCDouglas, SANeeb, MJ Development of potent and selective small-molecule human Urotensin-II antagonists. Bioorg Med Chem Lett18:3500-3 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50377216
n/a
NameBDBM50377216
Synonyms:CHEMBL256988
TypeSmall organic molecule
Emp. Form.C26H28Cl2N4O3
Mol. Mass.515.432
SMILESClc1cc2ncc(=O)n(CC(=O)N3CCCC(C3CN3CCOCC3)c3ccccc3)c2cc1Cl |w:17.18,16.26|
Structure
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